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New study of blast explosions has important implications for veterans
A new report that shows the effects of blast explosions on the human brain has important implications for veterans who suffer from post-traumatic stress and traumatic brain injury. The findings, as reported in The Lancet Neurology, also have important implications for their families and their caregivers.
The report sheds light on an area of medical science that has been poorly understood. Ever since the term “shell shock” was coined during World War I to describe the stunning concussive effects of bombs, those who survived bombing attacks without visible wounds were often regarded as weak or cowardly.
In more recent times, clinicians and scientists have been left to speculate about the cause of the mental and behavioral changes in military service members exposed to blasts. People often have assumed these problems are entirely psychological. This new information indicates that blast-related concussion and post-traumatic stress may have real anatomical explanations. You actually can see those explanations under a microscope.
In this new report, a series of autopsies of men who had been exposed to explosive blasts and later died from a variety of causes has found evidence of inflammation and scarring in regions of the brain that had been previously unreported. A team led by neuropathologist Dr. Daniel Perl, professor at the Uniformed Services University of Health Sciences, has detected microscopic changes in brain tissue at junctions with fluid on the surface of the brain, areas adjacent to fluid-filled chambers inside the brain, and along the brain’s blood vessels.
The distinct pattern of scarring seen in these regions is consistent with animal models of the physics of blast brain injury. The patterns demonstrate that explosive forces transmitted by fluid waves cause damage to brain tissue where those tissues meet up with these fluids inside the head.
The scars cannot be seen on brain imaging studies, including advanced MRI scans, but can be seen under a microscope. The abnormalities also are different from those of chronic traumatic encephalopathy, or CTE, which has been reported in some football players and other athletes who sustained direct blows to the head.
Currently, only an autopsy can diagnose this type of brain injury with certainty. To make sure the abnormal findings were not due to other causes, those with blast-related brain injury were compared to the autopsies of men known to have traumatic brain injury from other causes. They also were compared to those whose deaths were related to drug overdose. None of the other groups exhibited the type or pattern of scarring seen in blast-related brain injury group.
The new pathological findings reported in this study may very well explain the lingering effects of concussion from blast injury. Those effects include headache, memory impairment, and sleep disturbance. This study may also contribute to our understanding of post-traumatic stress, depression, and anxiety related to blast exposure in combat.
Stress reactions can still occur without the damaging effects of concussive blast waves, so this report cannot be viewed as an adequate explanation for all cases of post-traumatic stress. There is no reason to assume that all individuals exposed to blasts in the war zone or in training have the type of brain injury seen in this scientific report. More research is needed to help determine why some people experience the lingering cognitive and emotional effects of blasts while others do not.
Great strides have been made in the medical and psychological treatments for those in military and civilian life with "invisible wounds." Thanks to the publication of these new observations, perhaps some of what has been “invisible” has now become visible.
James Kelly, MA, MD, FAAN, a neurologist, is one of America’s top experts on treating concussions. With 32 years of experience, Dr. Kelly has worked with countless patients with traumatic brain injuries and has researched concussions in athletes and military personnel. In 2015, Dr. Kelly was named one of the Top Doctors in America in Neurology by Castle Connolly. Dr. Kelly is currently serving as a private consultant and Clinical Professor at The University of Colorado School of Medicine. The Military Service Initiative has engaged the services of Dr. Kelly as Senior Fellow for Wellness to help guide 2016 efforts in support of the Invictus Games and beyond.
Dr. Kelly served as the founder and director of National Intrepid Center of Excellence (NICoE), a Department of Defense institute that provides cutting-edge evaluation, treatment planning, research and education for service members and their families. NICoE also treats complex interactions of mild and traumatic brain injuries and psychological health conditions, conducts research, and provides clinical patient care.
His past positions also include assistant dean for graduate medical education at the University of Colorado School of Medicine, and the neurology residency program director at Northwestern University Feinberg School of Medicine.
Dr. Kelly has also served as director of the Brain Injury Program at the Rehabilitation Institute of Chicago. He was the neurological consultant for the Chicago Bears of the National Football League and is consulted frequently by professional, elite amateur and youth athletes who have sustained concussions. Kelly co-authored the sports concussion guidelines of the American Academy of Neurology and the Standardized Assessment of Concussion that is widely used in athletic and military settings worldwide.
Dr. Kelly completed a residency at the University of Colorado, internship in neurology at Michigan State University at Kalamazoo, and coursework at Northwestern University Feinberg School of Medicine, and earned a master's degree in psychology at Western Michigan University. He is also certified in neurology by the American Board of Psychiatry and Neurology and is a fellow of the American Academy of Neurology.Full Bio
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