Tayzar San is executive director of the Yone Kyi Yar Knowledge Propagation Society (KPS), an organization founded by young doctors, engineers, and students to promote a knowledge-based society in Burma. KPS engages in political education training, civic affairs workshops, and intellectual seminars. In 2015, he participated in the international conference entitled "Strengthening Democracy in Asia: Inclusion, Participation, and Rights" in New Delhi, India, which was organized by the World Movement for Democracy, the Asia Democracy Network, and the Institute of Social Sciences in India.
In 2011, Tayzar San founded the Beautiful Mind Foundation in Mandalay to provide free health care services to the poor. He chaired the organization in 2011 and 2012, and now serves as an executive committee member and volunteer doctor. In 2012, he re-founded and served as chairman of the Mandalay District All Burma Federation of Students Union. Tayzar San is also founder and secretary of the Art and Literature Association at the University of Medicine, Mandalay, which publishes a quarterly magazine. He graduated with an MBBS degree from the University of Medicine-Mandalay at 2013.